Publications

• Two distinct classes of cochaperones compete for the EEVD motif in heat shock protein 70 to tune its chaperone activities

  Johnson, O. T., Nadel, C. M., Carroll, E. C., Arhar, T.*, Gestwicki, J. E.*

  J. Biol. Chem., 2022, 298, 1016971. (*Co-corresponding authors).

• The interactions of molecular chaperones with client proteins: why are they so weak?

  Arhar, T., Shkedi, A., Nadel, C. M., Gestwicki, J. E.

  J. Biol. Chem., 2021, 297, 101282.

• Functional genomics screen identifies proteostasis targets that modulate Prion Protein (PrP) stability

  Abrams, J. L.*, Arhar, T.*, Mok, S. A., Taylor, I. R., Kampmann, M., Gestwicki, J. E.

  Cell Stress Chaperones, 2021, 26, 443-452. (*Contributed equally to this work).

• Robust Sequence Determinants of α-Synuclein Toxicity in Yeast Implicate Membrane Binding

  Newberry, R. W., Arhar, T., Costello, J., Hartoularos, G. C., Maxwell, A. M., Naing, Z. Z. C., Pittman, M., Reddy, N. R., Schwarz, D. M. C., Wassarman, D. R., Wu, T. S., Barrero, D., Caggiano, C., Catching, A., Cavazos, T. B., Estes, L. S., Faust, B., Fink, E. A., Goldman, M. A., Gomez, Y. K., Gordon, M. G., Gunsalus, L. M., Hoppe, N., Jaime-Garza, M., Navarro, E. J., Palar, A., Pellegrino, J., Saylor, W., Stephens, C. A., Strickland, J., Torosyan, H., Wankowicz, S. A., Wong, D. R., Wong, G., Redding, S., Chow, E. D., DeGrado, W. F., Kampmann, M.

  ACS Chem. Biol., 2020, 15, 2137–2153.

• Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis

  Sohn, P. D., Huang, C. T., Yan, R., Fan, L., Tracy, T. E., Camargo, C. M., Montgomery, K. M., Arhar, T., Mok, S. A., Freilich, R., Baik, J., He, M., Gong, S., Roberson, E. D., Karch, C. M., Gestwicki, J. E., Xu, K., Kosik, K. S., Gan, L.

  Neuron, 2019, 104, 458-470.

• Mapping Interactions with the Chaperone Network Reveals Proteostasis Factors that Protect Against Tau Aggregation.

  Mok, S. A., Condello, C., Freilich, R., Gillies, A., Arhar, T., Oroz, J., Kadavath, H., Julien, O., Assimon, V. A., Rauch, J. N., Dunyak, B. M., Lee, J., Tsai, F. T. F., Wilson, M. R., Zweckstetter, M., Dickey, C. A., Gestwicki, J. E.

  Nat. Struct. Mol. Biol., 2018, 25, 384-393.

• Protein-Protein Interactions (PPIs) in the Molecular Chaperone Network

  Freilich, R. E., Arhar, T., Abrams, J. L., Gestwicki, J. E.

  Acc. Chem. Res., 2018, 51, 940-949.

• Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance

  Mavor, D., Barlow, K. A., Asarnow, D., Birman, Y., Britain, D., Chen, W., Green, E. M., Kenner, L. R., Mensa, B., Morinishi, L. S., Nelson, C. A., Poss, E. M., Suresh, P., Tian, R., Arhar, T., Ary, B. E., Bauer, D. P., Bergman, I. D., Brunetti, R. M., Chio, C. M., Dai, S. A., Dickinson, M. S., Elledge, S. K., Helsell, C. V. M., Hendel, N. L., Kang, E., Kern, N., Khoroshkin, M. S., Kirkemo, L. L., Lewis, G. R., Lou, K., Marin, W. M., Maxwell, A. M., McTigue, P. F., Myers-Turnbull, D., Nagy, T. L., Natale, A. M., Oltion, K., Pourmal, S., Reder, G. K., Rettko, N. J., Rohweder, P. J., Schwarz, D. M. C., Tan, S. K., Thomas, P. V., Tibble, R. W., Town, J. P., Tsai, M. K., Ugur, F. S., Wassarman, D. R., Wolff, A. M., Wu, T. S., Bogdanoff, D., Li, J., Thorn, K. S., O’Conchuir, S., Swaney, D. L., Chow, E. D., Madhani, H. D., Redding, S., Bolon, D. N., Kortemme, T., DeRisi, J. L., Kampmann, M., Fraser, J. S.

  Biol. Open, 2018, 7, bio036103.

• Insertion of Perilipin 3 into a Glycero(phospho)lipid Monolayer Depends on Lipid Headgroup and Acyl Chain Species

  Mirheydari, M., Rathnayake, S. S., Frederick, H., Arhar, T., Mann, E. K., Cocklin, S., Kooijman, E. E.

  J. Lipid Res., 2016, 57, 1465-1476.

• Inhibition of Toxic IAPP Amyloid by Extracts of Common Fruits

  Kau, P. Y., Green, E., Pereira, C., Ekimura, S., Juarez, D., Whyte, T., Arhar, T., Malaspina, B., Nogaj, L. A., Moffet, D. A.

  J. Funct. Foods, 2015, 12, 450-457.